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c-Myc (9E10) Antibody DB098 0.100 mg/ml $300.00

Datasheet 
Datasheet 

For technical service please call (800) 595 1994
Product Info
Background The transcription factor c-Myc is a proto-oncogene that is at the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis (1-3). In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated (2&3).c-Myc also plays a pivotal role in apoptosis, most notably its connections to the CD95/Fas death receptor pathway (1&4). These different biological responses to c-Myc are most likely the result of different overlapping subsets of c-Myc target genes (1). 
Origin c-Myc (9E10) is provided mouse monoclonal IgG1 antibody, raised against a synthetic peptide corresponding to amino acids 408-439 within the carboxy terminal domain of human c-Myc. 
Product Details Each vial contains 100 µg/ml mouse monoclonal IgG1 c-Myc (9E10) DB098, in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Immunogen Synthetic peptide corresponding to amino acids 408-439 within the carboxy terminal domain of human c-Myc. 
Specificity c-Myc (9E10) DB098 reacts with c-Myc p67 of human origin 
Use Western blotting, immunopreciptation, and immunohistochemistry (including paraffin-embedded sections). Also recognizes the 9E10 c-Myc Tag. Recommended starting dilution for western bloting 1:100. 
Storage Store this product at 4º C, do not freeze. The product is stable for one year from the date of shipment. 
References 1. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. 2002. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21(21): 3414-3421.
2. Boxer LM, Dang CV. 2001. Translocations involving c-myc and c-myc function. Oncogene 20(40):5595-5610.
3. Dang CV, Resar LM, Emison E, Kim S, Li Q, Prescott JE, Wonsey D, Zeller K. 1999. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253(1): 63-77.
4. Prendergast GC. 1999. Mechanisms of apoptosis by c-Myc. Oncogene 18(19):2967-2987.
 

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Apoptosis/Tumor Suppressor Genes| Cell Adhesion| Cell Cycle| Controls| Fusion Protein/Epitope Tags| Growth Factors| Membrane Receptors
Protein Kinases| Secondary Antibodies| Signaling Intermediates| Transcription Regulation