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c-Myc (9E10) Antibody DB098 0.100 mg/ml $300.00


For technical service please call (800) 595 1994
Product Info
Background The transcription factor c-Myc is a proto-oncogene that is at the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis (1-3). In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated (2&3).c-Myc also plays a pivotal role in apoptosis, most notably its connections to the CD95/Fas death receptor pathway (1&4). These different biological responses to c-Myc are most likely the result of different overlapping subsets of c-Myc target genes (1). 
Origin c-Myc (9E10) is provided mouse monoclonal IgG1 antibody, raised against a synthetic peptide corresponding to amino acids 408-439 within the carboxy terminal domain of human c-Myc. 
Product Details Each vial contains 100 g/ml mouse monoclonal IgG1 c-Myc (9E10) DB098, in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Immunogen Synthetic peptide corresponding to amino acids 408-439 within the carboxy terminal domain of human c-Myc. 
Specificity c-Myc (9E10) DB098 reacts with c-Myc p67 of human origin 
Use Western blotting, immunopreciptation, and immunohistochemistry (including paraffin-embedded sections). Also recognizes the 9E10 c-Myc Tag. Recommended starting dilution for western bloting 1:100. 
Storage Store this product at 4 C, do not freeze. The product is stable for one year from the date of shipment. 
References 1. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. 2002. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21(21): 3414-3421.
2. Boxer LM, Dang CV. 2001. Translocations involving c-myc and c-myc function. Oncogene 20(40):5595-5610.
3. Dang CV, Resar LM, Emison E, Kim S, Li Q, Prescott JE, Wonsey D, Zeller K. 1999. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253(1): 63-77.
4. Prendergast GC. 1999. Mechanisms of apoptosis by c-Myc. Oncogene 18(19):2967-2987.

For Technical service please call +1-800-595-1994
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Apoptosis/Tumor Suppressor Genes| Cell Adhesion| Cell Cycle| Controls| Fusion Protein/Epitope Tags| Growth Factors| Membrane Receptors
Protein Kinases| Secondary Antibodies| Signaling Intermediates| Transcription Regulation